Derives de tetrahydrobenzimidazole substitues comme modulateurs de l'activite du tnf-a

Tetrahydrobenzimidazole derivatives as modulators of tnf activity

Abstract

A series of substituted 4,5,6,7-tetrahydrobenzimidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

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