Type v collagen-related molecules for the treatment of lung disease involving autoimmunity to type v collagen _________________________________________

Molecules apparentees au collagene de type v pour le traitement d'une maladie pulmonaire mettant en jeu l'auto-immunite au collagene de type v

Abstract

The present invention relates to treatment of medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. Specifically disclosed is a composition comprising Type V collagen or antigenic component thereof for the treatment of pulmonary disease, such as Idiopathic Pulmonary Fibrosis, Adult Respiratory Distress Syndrome, Acute Respiratory Distress Syndrome, secondary collagen vascular disease and any form of fibrotic lung disease, in a patient having autoimmunity to Type V collagen present in a lung. In some embodiments, the composition may further comprise cyclosporine. The composition may be used for oral feeding, intrapulmonary instillation, inhalation, subcutaneous injection, or intravenous injection.

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